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Ilker Tinay, MD, FEBU, FACS

Ilker Tinay, MD, FEBU, FACS

Urology-Urological Oncology

PROFESSIONAL SUMMARY


Physician-scientist with in-depth urological oncology experience in both clinical practice and academia


AREAS OF INTEREST


Rich experience in academic urological oncology, publishing, teaching and invited speaker experiences

Urological oncology opinion leader in Turkey

Urological oncology clinical Phase 3 trial experience

Deep understanding and experience with liquid biomarkers, namely microRNA in

prostate and urothelial carcinoma

Minimal invasive and open tumor surgery with particular expertise;

  • in prostate cancer

  • in kidney cancer

  • urothelial carcinoma of the bladder and upper urinary tract

  • retroperitoneal post-chemotherapy resection (RPLND) germ cell tumors


WORK EXPERIENCE


February 2020-Present: Anadolu Medical CenterDepartment of Urology/Uro-oncology

October 2017 - 2020: Associate Professor of Urology Marmara University School of Medicine

April 2014 – October 2017: Assistant Professor of Urology Marmara University School of Medicine

November 2011 – April 2014: University LecturerMarmara University School of Medicine

March 2010 – June 2011: UrologistKurtalan State Hospital, Siirt, TURKEY

March 2009 – March 2010: UrologistBalikesir Military Hospital, TURKEY


POSTGRADUATE TRAINING/ FELLOWSHIP APPOINTMENTS


April 2015 – September 2015 Clinical Observer(Robot Assisted Laparoscopic Surgery Urological Oncology) Steven L. ChangBrigham and Women’s HospitalHarvard Medical SchoolBoston, MA, USA

October 1, 2014 – September 30, 2015 Urologic Oncology Research Fellow Adam Kibel / Li Jia Research Lab Harvard Medical SchoolBoston, MA, USA

November 2003 – 2008 Residency Training Program in Urology,Department of Urology,Marmara University School of Medicine, Istanbul, Turkey

May 2007 Fellowship in Laparoscopic Urology, Heidelberg University Medical School, SLK Kliniken Heilbronn GmbH, Heilbronn, Germany

August – October 2005 Fellowship in Transplantation Surgery, Department of Surgery,Humboldt University School of Medicine, Berlin, Germany


MEDICAL SCHOOL EDUCATION


1997-2003 Istanbul Faculty of Medicine, Istanbul University, Turkey

July – August 2000 General Surgery and Colorectal Surgery Clerkship Cleveland Clinic Foundation, Cleveland, U.S.A

July – August 1999 Basic and Clinic Microbiology Clerkship Oslo University Hospital, Ulleval, Norway


CERTIFICATIONS


November 2008 Board Certified Urology (Turkey, active)

June 2010 Fellow of European Board of Urology (FEBU)

October 2018 Fellow of American College of Surgeons (FACS)


INTERNATIONAL MEMBERSHIPS


Member of the European Association of Urology

Member of American Urological Association

Member of American College of Surgeons

International Bladder Cancer Network


AWARDS

  1. Marmara University School of Medicine

Resident’s Science Encouragement Award – 2008

  1. Best Young Academician Oral Presentation AwardAnnual Congress of the Society of Urological Surgery in Turkey, 2012

  2. Association of Urooncology, Turkey - 2019 Scientific Research Award


INTERNATIONAL PEER REVIEWED PUBLICATIONS


1. Kidney loss due to periureteral fibrosis and ureteral obstruction secondary to migration of subureterically injected calcium hydroxylapatite. Önol FF, Tarcan T, Tinay I, Kotiloglu E, Simsek F. Journal of Pediatric Urology, 2006; 2 (5): 503-508


2. Long-term results of endoscopic treatment of vesicoureteral reflux with the sub- ureteric injection of calcium hydroxyapatite. Tarcan T, Tinay I, Temiz Y, Simsek F. International Urology and Nephrology 2007; 39(4): 1011-1014


3. A new suture technique for anastomosis in radical retropubic prostatectomy and early removal of urethral catheter. Türkeri L, Temiz Y, Yazıcı CM, Tinay I. The Canadian Journal of Urology 2007; 14(6): 3697-3701


4. Erectile dysfunction following Radiotherapy and Brachytherapy for prostate cancer. Akbal C, Tinay I, Simsek F, Turkeri L. International Urology and Nephrology 2008; 40(2): 355-63


5. Advances in the Understanding of the Early Detection of Bladder Cancer. Turkeri L and Tinay I. European Urological Review 2008; 3(2): 28-30


6. Outcome of preemptive penile rehabilitation before bilateral cavernosal nerve injury in rats. Tavukcu HH, Akbal C, Tinay I, Simsek F, Turkeri L. World Journal of Urology 2010; 28(6): 735-40


7. Recent Developments in Research and Treatment of Testicular Cancer: Highlights from Oncologic Congresses in 2009. Tinay I and Turkeri L. European Urology Supplements 2010; 9(3): 462-466


8. The value of sacral skin lesions in predicting occult spinal dysraphism in children with voiding dysfunction and normal neurological examination. Tarcan T, Tinay I, Temiz Y, Alpay H, Ozek M, Simsek F. J Pediatr Urol. 2012; 8(1): 55-58


9. Intradetrusor botulinum neurotoxin A (BoNT-A) injections decrease bladder fibrosis secondary to partial urethral obstruction in the male rat model. Tinay I, Tanidir Y, Cikler E, Cetinel S, Tarcan T. Neurourol Urodyn. 2012; 31(4): 564-70


10. Beneficial effects of quercetin on rat urinary bladder after spinal cord injury. Cevik O, Ersahin M, Sener TE, Tinay I, Tarcan T, Cetinel S, Sener A, Toklu HZ and Sener G. Journal of Surgical Research, 2013


11. An Alternative for Short Renal Vein during Kidney Transplantation: Long-term Experience with Polyethylene Terephthalate (Dacron) Vascular Graft. Tinay I, Temiz Y, Ilker Y, Tuglular S and Turkeri L. Urology 2013; 82(1): 245-7


12. Quercetin treatment against ischemia/reperfusion injury in rat corpus cavernosum tissue: role on apoptosis and oxidative stress. Cevik O, Cadırcı S, Sener TE, Tınay I, Akbal C, Tavukçu HH, Cetinel S, Kıran D, Sener G. Free Radic Res. 2013; 47(9): 683- 91


13. Diagnostic value of the pediatric lower urinary tract symptom score in children with overactive bladder. Akbal C, Sahan A, Sener TE, Sahin B, Tinay I, Tarcan T, Simsek F. World Journal of Urology 2014; 32(1): 201-8


14. Melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats. Tavukçu HH, Sener TE, Tinay I, Akbal C, Ersahin M, Cevik O, Cadırcı S, Reiter RJ, Sener G. Clinical and Experimental Pharmacology and Physiology 2014; 41(4): 309-16


15. High rate of sexual dysfunction following surgery for rectal cancer. Attaallah W, Ertekin C, Tinay I, Yegen C. Annals Coloproctology 2014; 30(5): 210-5


16. Significance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high-risk non-muscle-invasive bladder cancer treated with maintenance intravesical Bacillus Calmette-Guérin. Baltacı S, Bozlu M, Yıldırım A, Gökçe MI, Tinay I, Aslan G, Can C, Türkeri L, Kuyumcuoglu U, Mungan A. BJU Int. 2015 Nov;116(5):721-6


17. Association of BK Virus Titers With Lymphocyte Count in Renal Transplant Patients. Velioglu A, Aksu B, Asicioglu E, Arıkan H, Tinay I, Yardimci S, Yegen C, Tuglular S, Ozener C. Transplant Proc. 2015 Jun;47(5):1421-4


18. Contemporary trends in high-dose interleukin-2 use for metastatic renal cell carcinoma in the United States. Allard CB, Gelpi-Hammerschmidt F, Harshman LC, Choueiri TK, Faiena I, Modi P, Chung BI, Tinay I, Singer EA, Chang SL. Urol Oncol. 2015 Nov;33(11):496.e11-6


19. The Contemporary Incidence and Sequelae of Rhabdomyolysis Following Extirpative Renal Surgery: A Population Based Analysis. Gelpi-Hammerschmidt F, Tinay I, Allard CB, Su LM, Preston MA, Trinh QD, Kibel AS, Wang Y, Chung BI, Chang SL. J Urol. 2016 Feb;195(2):399-405


20. Trends in utilization, perioperative outcomes and costs for nephroureterectomies in the management of upper tract urothelial carcinoma (UTUC): a 10-year population- based analysis. Tinay I, Gelpi-Hammerschmidt F, Leow JJ, Allard CB, Rodriguez D, Wang Y, Chung BI, Chang SL. BJU International (2015), Doi: 10.1111/bju


21. Antioxidant Agent Quercetin Prevents Impairment of Bladder Tissue Contractility and Apoptosis in a Rat Model of Ischemia/Reperfusion Injury. TINAY I, SENER TE, ÇEVIK Ö, CADIRCI S, TOKLU H, ÇETINEL S, SENER G, TARCAN T. LUTS: Lower Urinary Tract Symptoms (2015), Doi: 10.1111/luts.12125


22. Secretory leukocyte protease inhibitor is a survival and proliferation factor for castration resistant prostate cancer. Zheng D, Gui B, Gray KP, Tinay I, Rafiei S, Huang Q, Sweeney CJ, Kibel AS, Jia L. Oncogene (2016), Doi: 10.1038/onc.2016.13


23. Is 40?cm?H2O detrusor leak point pressure cut-off reliable for upper urinary tract protection in children with myelodysplasia? Tarcan T, Sekerci ÇA, Akbal C, Tinay I, Tanıdır Y, Sahan A, Sahin B, Top T, Simsek F. Neurourology and Urodynamics (2016), Doi: 10.1002/nau.23017


24. Differentiation of ureteral stones and phleboliths using Hounsfield units on computerized tomography: a new method without observer bias. Tanidir Y, Sahan A, Asutay MK, Sener TE, Talibzade F, Garayev A, Tinay I, Sekerci CA, Simsek F. Urolithiasis. 2017 Jun;45(3):323-328


25. The effect of doxazosin and sildenafil citrate combination on bladder tissue contractility, alpha adrenergic receptor, and iNOS subtype expression in a male rat model of partially bladder outlet obstruction. Gumrah A, Tanidir Y, Tinay I, Ozyurek M, Tarcan T. Neurourol Urodyn. 2017 Aug;36(6):1479-1487


26. The effect of intradetrusor botulinum neurotoxin type A on urinary NGF, TGF BETA- 1, TIMP-2 levels in children with neurogenic detrusor overactivity due to myelodysplasia. Top T, Sekerci CA, Isbilen-Basok B, Tanidir Y, Tinay I, Isman FK, Akbal C, Simsek F, Tarcan T. Neurourol Urodyn. 2017 Sep;36(7):1896-1902


27. Androgen receptor-regulated miRNA-193a-3p targets AJUBA to promote prostate cancer cell migration. Jia L, Gui B, Zheng D, Decker KF, Tinay I, Tan M, Wang X, Kibel AS. Prostate. 2017 Jun;77(9):1000-1011.


28. Full blown nephrotic syndrome due to unilateral obstruction of the uretero-pelvic junction. Atas DB, Arikan H, Tinay I, Asicioglu E, Velioglu A, Koc M, Tuglular S, Ozener C. Nephrology (Carlton). 2017 Jun;22(6):498


29. Clinical Case Discussion: Bilateral Synchronous Testicular Cancer and Organ- sparing Surgery. Sener TE, Ozveren B, Tinay I, Cam K, Turkeri L. Eur Urol Focus. 2016 Aug 23. pii: S2405-4569(16)30111-0. doi: 10.1016/j.euf.2016.08.003


30.Jia L, Gui B, Zheng D, Decker KF, Tinay I, Tan M, Wang X, Kibel AS. Androgen receptor-regulated miRNA-193a-3p targets AJUBA to promote prostate cancer cell migration. Prostate. 2017 Jun;77(9):1000-1011. doi: 10.1002/pros.23356


31.Sener TE, Ozveren B, Tinay I, Cam K, Turkeri L. Clinical Case Discussion: Bilateral Synchronous Testicular Cancer and Organ-sparing Surgery. Eur Urol Focus. 2016 Aug 23. pii:S2405-4569(16)30111-0. doi:10.1016/j.euf.2016.08.003


32.Tinay I, Aslan G, Kural AR, Özen H, Akdogan B, Yıldırım A, Ongün S, Özkan A,Esen T, Zorlu F, Dillioglugil Ö, Bekiroglu N, Türkeri L; Members of Urooncology Association. Pathologic Outcomes of Candidates for Active Surveillance Undergoing Radical Prostatectomy: Results from a Contemporary Turkish Patient Cohort. Urol Int. 2018;100(1):43-49. doi: 10.1159/000481266


33.Tinay I, Tan M, Gui B, Werner L, Kibel AS, Jia L. Functional roles and potential clinical application of miRNA-345-5p in prostate cancer. Prostate. 2018 Sep;78(12):927-937. doi: 10.1002/pros.23650


34.Sener TE, Tavukcu HH, Atasoy BM, Cevik O, Kaya OT, Cetinel S, Dagli Degerli A,Tinay I, Simsek F, Akbal C, Butticè S, Sener G. Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions. Int J Impot Res. 2018 Aug;30(4):179-188. doi: 10.1038/s41443-018-0042-6


35.Amuran GG, Eyuboglu IP, Tinay I, Akkiprik M. New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins. Med Sci (Basel). 2018 Dec 7;6(4). pii: E113. doi: 10.3390/medsci6040113. Review. PubMed PMID: 30544619; PubMed Central PMCID: PMC6318758.


36.Guran T, Yesil G, Turan S, Atay Z, Bozkurtlar E, Aghayev A, Gul S, Tinay I, Aru B, Arslan S, Koroglu MK, Ercan F, Demirel GY, Eren FS, Karademir B, Bereket A. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans. Eur J Endocrinol. 2019 May 1;180(5):291- 309. doi: 10.1530/EJE-19-0067. PubMed PMID: 30893644.


37.Baykan O, Akgul M, Uren N, Yaman A, Tinay I, Ergul E, Sazci A, Turkeri L, Haklar G. The Relationship Between Urothelial Type Bladder Cancer, Plasma 25-Hydroxyvitamin D Levels, and Vitamin D Receptor ApaI BsmI FokI, and TaqI Polymorphisms. Clin Lab. 2019 Apr 1;65(4). doi: 10.7754/Clin.Lab.2018.180339. PubMed PMID: 30969078.


38.Mehdiyev S, Velioglu A, Arikan H, Asicioglu E, Cincin A, Demirbas T, Tinay I, Ozener C, Tuglular S. Cardiac Risk Assessment in Kidney Transplant Candidates: Clinical Usefulness of Different Guidelines. Transplant Proc. 2019 May;51(4):1058-1063. doi: 10.1016/j.transproceed.2019.01.101. Epub 2019 Feb 8. PubMed PMID: 31101171.


39.Kanar BG, Ozben B, Sunbul M, Şener E, Ozkan O, Tınay I, Tigen MK. Androgen-deprivation therapy impairs left ventricle functions in prostate cancer patients. Int Urol Nephrol. 2019 Jul;51(7):1107-1112. doi: 10.1007/s11255-019- 02184-4. Epub 2019 Jun 4. PubMed PMID: 31165396.


40.Inanir S, Kesim S, Ergelen R, Tınay I, Türköz HK. 68Ga-PSMA PET/CT in Giant Retroperitoneal Liposarcoma. Clin Nucl Med. 2019 Nov;44(11):e612-e613. doi: 10.1097/RLU.0000000000002762. PubMed PMID: 31524684.


41.Güllü Amuran G, Tinay I, Filinte D, Ilgin C, Peker Eyüboglu I, Akkiprik M. Urinary micro-RNA expressions and protein concentrations may differentiate bladder cancer patients from healthy controls. Int Urol Nephrol. 2019 Nov 2. doi: 10.1007/s11255-019-02328-6. [Epub ahead of print] PubMed PMID: 31679136.


42.Nazım C Demircan, Özkan Alan, Tugba Basoglu Tüylü, Tugba AkınTelli, Rukiye Arıkan, Furkan C Çiçek, Özlem Ercelep, Mehmet AÖztürk, Ilknur Alsan Çetin, Rabia Ergelen, Ilker Tinay, Nalan Akgül Babacan, Serap Kaya, Faysal Dane, Perran F Yumuk. Impact of the Charlson Comorbidity Index on Dose-Limiting Toxicity and Survival in Locally Advanced and Metastatic Renal Cell Carcinoma Patients Treated With First-Line Sunitinib or Pazopanib [published online ahead of print, 2019 Dec 2]. J Oncol Pharm Pract. 2019;1078155219890032. doi:10.1177/1078155219890032


43.The Early Impact of COVID-19 Pandemic on Surgical Urologic Oncology Practice in Turkey: Multi-Institutional Experience From Different Geographic Areas.Tinay I, Ozden E, Suer E, Bozkurt O, Izol V, Sahin B, Turkeri L.Urology. 2020 Aug;142:29-31

44. Hyperbaric oxygen therapy prevents subarachnoid hemorrhage-induced apoptosis and impaired contractility of the rabbit bladder.Tinay I, Celik O, Sekerci CA, Cadirci S, Cevik O, Oroglu B, Sener G, Tarcan T.Neurourol Urodyn. 2020 Jun;39(5):1276-1282


44.Re: Marc-Oliver Grimm, Antione G. van der Heijden, Marc Colombel, et al. Non- muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial "NIMBUS". Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.04.066. Karabay E, Tınay I.Eur Urol. 2020 Oct;78(4):e161-e162


45.The impact of tumor invasion to muscularis mucosaevascular plexus on patient outcome in pT1 bladder urothelial carcinoma.Sahan A, Gerin F, Garayev A, Bozkurtlar E, Çubuk A, Ozkaptan O, Ertas K, Tanıdır Y, Cam HK, Tınay I.Arch Ital Urol Androl. 2020 Oct 2;92(3)


46.The Effect of Diagnostic Ureterorenoscopy on Intravesical Recurrence in Patients Undergoing Nephroureterectomy for Primary Upper Tract Urinary Carcinoma.Izol V, Deger M, Ozden E, Bolat D, Argun B, Baltaci S, Celik O, Akgul HM, Tinay I, Bayazit Y; Bladder Cancer Study Group of Association of Urooncology, Turkey.Urol Int. 2020 Dec 2:1-7


47. Ta grade 3/high grade non-invasive bladder cancer: Should we perform a second TUR? Tinay I, Baltaci S, Demirdag C, Akdogan B, Yucetas U, Simsekoglu MF, Haberal HB, Bozlu M, Izol V, Aslan G, Bekiroglu N; Bladder Cancer Study Group of Urooncology Association, Turkey.Int J Clin Pract. 2020 Dec 10:e13924

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